Inhaled
Steroids for Asthma Increase Heart Disease Risk
Glucocorticoids
are used to treat asthma. The
use of glucocorticoids, anti-inflammatory drugs commonly prescribed
for conditions such as asthma, rheumatoid arthritis and inflammatory
bowel disease, may increase the risk of cardiovascular disease by
up to 70 percent, according to a study.
The study involved 164,000
people from Scotland, almost half of who had received at least
one glucocorticoid prescription between 1993
and 1996. Glucocorticoids,also
known as corticosteroids, are related to cortisol, a steroid hormone naturally
produced by the body.
Researchers found that the higher
the dose of the drug taken, the greater the risk of heart disease
appeared to be.
Among people who had taken the drug
at the highest doses for 10 years, about two percent of the group,
the risk of
heart disease in those over 40 years
of age increased from about 19 people in every 100 to 32 in 100.
Additionally, the drugs are associated with several serious side effects
including thinning of the bones, infections, susceptibility to bruising,
diabetes, cataracts,
glaucoma, high blood pressure and weight gain.
However, researchers noted
that it is unclear whether the underlying conditions or the medication
were causing the increased risk of heart disease.
They say that doctors
should be cautious in prescribing high doses of the drugs for long
periods of time, especially in cases where the patient is
already
at a greater risk of cardiovascular disease.
SOURCE: BBC News March 24, 2003
|